High-precision temperature control solutions for biotechnology
Precise temperatures are crucial for reproducible results in biotechnology. In addition to their unbeatable accuracy, the strengths of our temperature control units lie in their
In biotechnology, precise temperature control has a decisive influence on production performance or research results. Our temperature control units ensure exact temperatures and stable, reproducible process conditions in research laboratories and production plants.
The dynamic temperature control systems of the Unistat series are predestined for chemical and bioreactors, autoclaves, miniplants and pilot plants, reaction blocks, calorimeters and distillation plants. Especially for cooling fermenters and bioreactors, the HTS circulating heat exchangers are recommended for connection to existing cooling water/soil.
Glass jacketed reactors are a common tool in the chemical and pharmaceutical industries. The quality of temperature control depends heavily on the speed at which the jacket temperature can be changed. For best possible heat transfer rates, unistats produce a high delta-T between jacket temperature and reactor contents. Glass reactors are inherently sensitive to pressure (typically the maximum allowable jacket pressure is 0.5 bar) and thermal shock (caused by the temperature difference between the jacket and the reaction mass). Uni¬states have variable pressure control (VPC) and a delta-T limit to protect against both. In addition, the "process safety" function ensures that the pump and cooling system continue to operate in the event of an overtemperature shutdown. This can prevent overheating of the reactor contents during an exothermic reaction, for example.
The metal component of the reactor has a different coefficient of expansion than the glass liner. To protect against bursting of the glass due to too rapid heating or cooling, the ramp rate can be set and controlled to change the temperature of the cladding at a non-critical rate. Alternatively, a "dwell" time can be programmed to allow the glass to adjust slowly.
Stainless steel reactors
These reactors are robust and are generally not subject to damage from jacket pressure or rapid thermal changes.
Flow reactors are increasingly used in research and production. Huber devices from the simple CC-304B to large unistats are used in this application. Some of these reactors have high flow resistance. Unistats provide sufficient pressure to ensure maximum heat transfer flow for the best possible temperature control in the reaction zones within the flow reactor.
Unistats are capable of extremely fast temperature changes, e.g. to control the high-energy reactions often carried out in pressurized reactors (glass/metal). The Unistat T series is often used for such high temperature reactions. Due to the hydraulic seal, no vapors are generated from the heat transfer fluid. To protect the heat transfer fluid from environmental influences, a special sealing kit is available for overlaying with nitrogen gas.
Often bioreactors can only use water or water/glycol as a heat transfer medium. After a process, the bioreactors must be cleaned and sterilized "Cleaned In Place" (CIP) and "Sterilised In Place" (SIP). These routines are performed at temperatures up to 120 °C with steam (The temperature range of the Huber Unichiller T-H can be extended to +120 °C). Before this can be done, the jacket of the bioreactor must be drained of the water/glycol. A series of valves can be used to drain the reactor jacket into a storage tank and after completion of the SIP. The system can be refilled by starting the chiller pump.
Controlled freezing & thawing
Some preparations must be frozen at a predefined speed and then thawed at a predefined speed. The built-in programmer in the Pilot ONE allows the creation of several programs, which can be stored either in the memory of the Pilot ONE or on a data carrier via the USB interface. The creation of a program is very flexible and yet extremely easy to implement, thanks to the simple graphic display. The frozen blocks of medical preparation can be thawed in a special bath. These baths are tempered by a programmed Unichiller. The Unichiller "eo" versions (externally open) allow direct contact of the heat exchange medium (water-glycol mixture) with the baths for efficient heat transfer. Unistat technology can also be used for freezing and thawing applications.
Temperature control for various applications in the glove box can be achieved with unistats, chillers and immersion chillers from the TC range.
Rheometer, viscometer To ensure accurate and constant temperature control of a sample during the test, the Mini¬stat or a device of the series "K" is used. These devices are ideal for the control of viscometer samples: compact, flexible and a thermal stability of 0.02 K.
Analytical laboratory equipment
Various analytical laboratory instruments such as X-ray diffractometers, mass spectrometers, etc. produce heat that must be effectively dissipated. Huber chillers as a source of external cooling with their compact design and small footprint save valuable space in the laboratory.
Circulating heat exchancers
The thermostat program is divided into two product lines, the CC models and the simpler KISS models. Both model lines are classically designed laboratory thermostats with an open bath.
Circulating heat exchanger
Circulating heat exchanger with circulating pump for primary side connection to existing cooling water.
Unichillers up to 10 kW
Unichillers with cooling capacities up to 10 kW offer the best efficiencies, stable pressure and flow rates and a constant cooling water temperature. The units are suitable for heat removal in biological and chemical processes and for cooling technical equipment.
Unichillers up to 80 kW
Unichillers with cooling capacities up to 80 kW are tower-type circulators with a small footprint and air- or water-cooled chiller. The units are suitable for cooling industrial and chemical processes and as a central cooling water supply.