Chemicals / Pharmaceuticals
High-precision temperature control solutions for the chemical and pharmaceutical industry
Companies from the chemical and pharmaceutical industries work at the highest level. Safety and efficiency play a central role. As technological leaders, our temperature control units score with
- efficient tempering and accurate results
- low operating costs
- extensive safety features for unattended continuous operation
In chemical reaction engineering, precise temperature control has a decisive influence on production output or research results. Unistat temperature control systems ensure exact temperatures and stable process conditions in numerous research laboratories, pilot plants and kilo labs.
With the Unistat hybrid technology, we also offer solutions for very large reaction vessels of 10,000 liters and more. Due to their thermodynamic properties, Unistats are regarded as technological leaders. This is not least due to the fact that the units are continuously developed further together with process engineers and adapted to current requirements. Unistats are therefore predestined for chemical and bioreactors, autoclaves, miniplant and pilot plants, reaction blocks, calorimeters and distillation plants. The units impress with short heating and cooling times, wide temperature ranges without liquid changes, and high stability and reproducibility throughout the entire temperature control process.
Reactors with glass jackets are a common tool in the chemical and pharmaceutical industries. The quality of temperature control is highly dependent on the speed at which the jacket temperature can be changed. For best possible heat transfer rates, unistats produce a high delta-T between jacket temperature and reactor contents. Glass reactors are inherently sensitive to pressure (typically the maximum allowable jacket pressure is 0.5 bar) and thermal shock (caused by the temperature difference between the jacket and the reaction mass). Unistats have variable pressure control (VPC) and a delta-T limit to protect against both. In addition, the "process safety" function ensures that the pump and cooling system continue to operate in the event of an overtemperature shutdown. This can, for example, prevent overheating of the reactor contents during an exothermic reaction.
The metal component of the reactor has a different coefficient of expansion than the glass liner. To protect against bursting of the glass due to too rapid heating or cooling, the ramp rate can be set and controlled to change the temperature of the cladding at a non-critical rate. Alternatively, a "dwell" time can be programmed to allow the glass to adjust slowly.
Stainless steel reactors
These reactors are robust and are generally not subject to damage from jacket pressure or rapid thermal changes.
Flow reactors are increasingly used in research and production. Huber devices ranging from the simple CC-304B to large unistats are used in this application. Some of these reactors have high flow resistance. Unistats provide sufficient pressure to ensure maximum heat transfer flow for the best possible temperature control in the reaction zones within the flow reactor.
Unistats are capable of extremely fast temperature changes, e.g. to control the high-energy reactions often performed in pressurized reactors (glass/metal). The Unistat T series is often used for such high temperature reactions. Due to the hydraulic seal, no vapors are generated from the heat transfer fluid. To protect the heat transfer fluid from environmental influences, a special sealing kit is available for overlaying with nitrogen gas.
Often bioreactors can only use water or water/glycol as a heat transfer medium. After a process, the bioreactors must be cleaned and sterilized "Cleaned In Place" (CIP) and "Sterilised In Place" (SIP). These routines are performed at temperatures up to 120 °C with steam (The temperature range of the Huber Unichiller T-H can be extended to +120 °C). Before this can be done, the jacket of the bioreactor must be drained of the water/glycol. A series of valves can be used to drain the reactor jacket into a storage tank and after completion of the SIP. The system can be refilled by starting the chiller pump. The storage tank/expansion tank can be manufactured separately by Huber. Piping, valves, etc. must be carried out on site.
Controlled freezing & thawing
Some preparations must be frozen at a predefined speed and then thawed at a predefined speed. The built-in programmer in the Pilot ONE allows the creation of several programs, which can be stored either in the memory of the Pilot ONE or on a data carrier via the USB interface. The creation of a program is very flexible and yet extremely easy to implement, thanks to the simple graphic display. The frozen blocks of medical preparation can be thawed in a special bath. These baths are tempered by a programmed Unichiller. The Unichiller "eo" versions (externally open) allow direct contact of the heat exchange medium (water-glycol mixture) with the baths for efficient heat transfer. The Unistat technology can equally be used for freezing and thawing applications.
Temperature control for various applications in the glove box can be achieved with unistats, unichillers and immersion coolers from the TC range.
Huber recirculating chillers have a small internal volume so that the cooling power generated is more concentrated on the application. Instead of wasting cooling capacity on a huge reservoir, other applications can be connected.
Analytical laboratory equipment
Various analytical laboratory instruments such as X-ray diffractometers, mass spectrometers, etc. produce heat that must be effectively dissipated. Huber chillers as a source of external cooling with their compact design and small footprint save valuable space in the laboratory.
Circulating heaters for temperature control of externally connected, open systems. With compact design and circulation pump made of stainless steel.
Circulating heat exchanger
Circulating heat exchanger with circulating pump for primary side connection to existing cooling water.
Dynamic temperature control systems
Unistats are the ideal solution when it comes to fast and highly accurate temperature control of externally connected applications.
Recirculating chillers of the Unichiller series offer ideal solutions for environmentally friendly and economical cooling in laboratories and industry.